Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series.

Authors: Lucas Elms, Scott Shannon, Shannon Hughes, and Nicole Lewis. Background: In the US Post Traumatic Stress Disorder (PTSD) has a lifetime prevalence of 6.1%, making it a relatively common condition. In addition to anxiety, PTSD is characterized by re-experiencing traumatic events, avoidance of distressing factors, and alterations in mood, arousal, and cognition. There is accumulating evidence that

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Evaluation of pharmacokinetics and acute anti-inflammatory potential of two oral cannabidiol preparations in healthy adults

Authors: Jack M. Hobbs, Allegra R. Vazquez, Nicholas D. Remijan, Roxanne E. Trotter, Thomas V. McMillan, Kimberly E. Freedman, Yuren Wei, Keith A. Woelfel, Olivia R. Arnold, Lisa M. Wolfe, Sarah A. Johnson, Tiffany L. Weir. Background: CBD is a “lipophilic” or lipid-soluble molecule, meaning that it dissolves in oil. This presents a challenge, because fat soluble molecules

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fringe cbd and tree trunks

Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts.

J Bone Miner Res 2015 Oct;30(10):1905-13. doi: 10.1002/jbmr.2513. Epub 2015 May 10.Authors: N. Kogan, E. Melamed, et al. Background: Bones contain a fully functional endocannabinoid system (ECS), which is one of the systems that CBD interacts with. The ECS is known to regulate bone mass and skeletal remodeling. Osteoclasts, the cells that break down bones, are

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Fish oil, cannabidiol and the gut microbiota: An investigation in a murine model of colitis

Authors:C. Silvestri, E. Pagno, S. Lacrois, T. Venneri, C. Cristiano, A. Calignano, O.A. Parisi, A.A. Izzo, V. Di Marzo & F. Borrelli.Background:Inflammatory Bowel Disorders (IBD) affects around 3 million Americans. A clinically important observation is that IBD is associated with alterations of the gut microbiome. While CBD is known to affect inflammation, it was hypothesized

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Can CBD Consumption Negatively Impact the Liver?

Background:The FDA recently requested that human research looking at the effect of CBD on liver function be conducted. In response, 12 CBD companies funded a research study looking at CBD and liver health over a 7-month period. Previously, in 2019, findings from a mouse study suggested that extremely high levels of CBD might cause liver

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The Effects of Cannabidiol and Analgesic Expectancies on Experimental Pain Reactivity 11/12/21

The Effects of Cannabidiol and Analgesic Expectancies on Experimental Pain Reactivity in Healthy Adults: A Balanced Placebo Design Trial Authors: Martin J. De Vita, Stephen A. Maisto, Christina E. Gilmour, Lauren McGuire, Elizabeth Tarvin, and Dezarie Moska. http://dx.doi.org/10.1037/pha0000465   Who was it? Fifteen healthy men and women aged 18-30 years participated in this study. Subjects

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Can Cannabis Be Used to Improve Sleep?

SleepSleep is an incredibly important predictor of health: getting less than 6 hours of sleep on a continuous basis makes you 48% more likely to die of heart disease and 15% more likely to have a stroke1. Although scientists are still not really sure why sleep is so good for us, they’ve recently discovered that

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Study: Water Soluble CBD

Buying CBD in the US today can be a dizzying experience. The sheer volume of products is overwhelming, many of which claim to have unique and distinctive properties. Among the newer CBD products on the market are water soluble ones, which claim to offer better absorption and to be more bioavailable to the body. That

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Topical and Transdermal CBD: Research Evidence and Applications

There are many CBD products available today that are designed to be applied directly to the skin. The skin is the largest organ in the body, whose main function is to provide a barrier between the environment and the inside of the body. The skin protects us from many things, including UV radiation, allergens, chemicals,

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The Cannabis Entourage Effect – Does the Truth Live Up to the Hype?

A few months ago I attended a doctor’s appointment with a family member wanting to get a medical cannabis prescription for an ongoing neurological condition. Among the products recommended was a full spectrum CBD product, which we were told was superior to CBD isolate products due to the “entourage effect.” I’d heard about this effect

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Can Cannabis Be Used to Reduce Depression?

Depression affects 322 million people worldwide1 with a lifetime prevalence of 20%2. In the United States, $71 billion is spent treating depression each year by individual patients, government, and insurance programs, and depressive disorders are the sixth most costly health condition overall3. Depression tends to be chronic with high rates of recurrence and remission4.  Depression is widely

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CBD and Anxiety

Anxiety disorders, the most common of which are generalized anxiety disorder (GAD), panic disorder (PD), and social anxiety disorder (SAD), are the most prevalent mental illnesses in the world1. It has been estimated that 28% of Americans will suffer from an anxiety disorder at some point in their life, with an economic cost of 42.3

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CBD and Pain

Approximately 50 million Americans, or around 20%, have some form of chronic pain1. The cost of treating pain in the US is staggering: annually, it has been shown to cost up to $635 billion2. These costs increase as pain severity worsens, which it often does for many people. Even more concerning is how pain affects

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CBD and Peripheral Neuropathy

The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities Authors: Dixon Xu, Benjamin Cullen, Meng Tang, and Yujiang Fang.Citation: Current Pharmaceutical Biotechnology, 2020, 21, 390-402 • https://www.eurekaselect.com/177080/article Who Was It?Patients with symptomatic peripheral neuropathy were treated with either topical CBD (15 patients) or placebo (14 patients). The groups were randomly

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CBD and the Experience of Pain

In a recently published clinical trial, a single dose of CBD isolate reduced the way subjects experienced pain. The study used a double-blind, placebo-controlled crossover design, which is the gold standard in research. Subjects consumed 50mg of oil-based CBD and 30 minutes later, pain was generated experimentally using heat. People taking CBD just weren’t bothered

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CBD is being used for pain, sleep, mental health, and general well-being.

In a recent survey of CBD users, 42.6% used CBD for anxiety, 42.5% for sleep issues, 37.5% for stress, and 37% for general health and well-being. People also reported using CBD for a variety of pain conditions, including chronic pain, pain from arthritis, fibromyalgia, menstrual pain, and headache and migraines.  Patterns of CBD use vary

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CBD is a popular consumer health product being used widely in the United States. Consumers are using CBD to treat a diverse range of health conditions.

Over ¼ of US adults report using CBD products in the past year. In a recent survey, 26.1% of US adults aged 16 to 65 reported using CBD products over the past 12 months. CBD use was slightly higher in women and in adults aged 26-35. Almost 40% of CBD users have never used cannabis. 

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Anxiolytic Effects of Repeated CBD Treatment in Teenagers With Social Anxiety Disorders

Nearly 1 in 8 people suffer from Social Anxiety Disorder at some point in their life. Social Anxiety Disorder (SAD) is a condition in which people experience excessive anxiety in situations where they may feel judged or embarrassed. SAD often begins in adolescence but may also be experienced in childhood, and many people report that

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