C. Silvestri, E. Pagno, S. Lacrois, T. Venneri, C. Cristiano, A. Calignano, O.A. Parisi, A.A. Izzo, V. Di Marzo & F. Borrelli.
Inflammatory Bowel Disorders (IBD) affects around 3 million Americans. A clinically important observation is that IBD is associated with alterations of the gut microbiome. While CBD is known to affect inflammation, it was hypothesized that CBD might also alleviate IBD through effects on the microbiome. Fish oil also has anti-inflammatory properties and affects the microbiome and might be a good adjunct to CBD in IBD treatment.
Who was it? This study used an animal model of IBD called experimental murine colitis. The mice used in the study were adult males who developed colitis following chemical toxin exposure.
What was done? There were four experiments done using different doses and combinations of fish oil and CBD. Inflammation was assessed at two time points. Intestinal health and fecal microbiota were also assessed.
CBD co-administered with fish oil reduced intestinal inflammation. All inflammatory markers, including IL-6, IL-10, and intestinal permeability were decreased. Levels of A. muciniphilia, which has anti-inflammatory effects, increased with CBD/fish oil treatment.
Many dietary supplements are known to have anti-inflammatory action and might work synergistically with CBD. In this study, it was found that CBD combined with fish oil reduced inflammation in a mouse model of IBD and had a positive effect on a species of anti-inflammatory gut bacteria. Fish oil is a source of omega-3 fatty fatty acids, which have many health promoting effects. CBD could be combined with fish oil in the treatment of inflammatory conditions or as part of a regular wellness regime.