November 5, 2021

The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities


Authors: Dixon Xu, Benjamin Cullen, Meng Tang, and Yujiang Fang.

Citation: Current Pharmaceutical Biotechnology, 2020, 21, 390-402 •


Who Was It?

Patients with symptomatic peripheral neuropathy were treated with either topical CBD (15 patients) or placebo (14 patients). The groups were randomly assigned and both patients and researchers were blinded to the treatment group. Patients had been symptomatic for at least three months.


What Was Done?

Patients were treated with either CBD or placebo for a period of four weeks. The CBD group received CBD oil while the placebo group received emu oil which was applied directly to the skin. Patients were instructed to apply the treatment to symptomatic areas, up to four times per day. Pain and other sensations were evaluated at baseline, 2 weeks, and 4 weeks. Pain quality, location, and intensity was assessed.

What Happened? Compared to placebo, intense pain, sharp pain, cold and itchy sensations were decreased in the CBD group. CBD was well tolerated with no adverse events reported.


Fringe Commentary 

This study is very exciting, as it is the first and only clinical trial to date that has used topically applied CBD to relieve pain. CBD was shown to significantly reduce pain and other unpleasant sensations and was very well tolerated, suggesting that it can be used safely in the treatment of peripheral neuropathy. Peripheral neuropathy is a painful condition for which traditional pharmacologic treatments often fail to relieve symptoms, and many patients are seeking alternative therapies. Fringe Mysa is a topical CBD product that contains CBD isolate from hemp extract along with other skin soothing ingredients including lavender and lemon oil, vitamin E, aloe leaf juice, and Yuzu. Topically applied CBD does not pass into the bloodstream, making it a great option for treatment of localized pain conditions. 
About the Author Dr. Genevieve Newton

Dr. Genevieve Newton, DC, PhD has spent the past 19 years as a researcher and educator in the field of nutritional sciences. A series of personal health crises led her to discover the benefits of cannabinoids, and she soon found herself engrossed in studying the endocannabinoid system and therapeutic applications of cannabis/cannabinoids in mental health, pain, sleep, and neurological disorders. She has recently taken a position as the Scientific Director at Fringe, a new medical CBD and education company.

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